Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Fernando M. Pimentel-Santos; Ana Filipa Mourão; Célia Ribeiro; José Costa; Helena Santos; Anabela Barcelos; Patricia Pinto; Fátima Godinho; Margarida Cruz; Elsa Vieira-Sousa; Rui André Santos; Sara Rabiais; Jorge Félix; João Eurico Fonseca; Henrique Guedes-Pinto; Matthew A. Brown; Jaime C. Branco; A. F. Mourão; A. A. De Matos; C. Ribeiro; F. M. Pimentel-Santos; J. Bravo Pimentão; M. Mateus; P. Nero; P. Araújo; S. Falcão; T. L. Pinto; W. Castelão; E. Vieira De Sousa; J. Caetano-Lopes; J. E. Fonseca; C. Silva; E. Simões; H. Madeira; H. Santos; J. Vaz Patto; J. Ferreira; M. Micaelo; M. J. Mediavilla; M. Sousa; P. Soares Branco; F. Godinho; J. Canas Da Silva; S. Garcês; V. Tavares; A. Ribeiro; D. Araújo; J. A. Costa; L. Costa; M. C. Afonso; M. Bogas; S. Alcino; P. Pinto; A. R. Cravo; G. Sequeira; R. A. Santos; A. Barcelos; I. Cunha; M. Cruz

doi:10.1007/s10067-011-1854-7

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Fernando M. Pimentel-Santos, Ana Filipa Mourão, Célia Ribeiro, José Costa, Helena Santos, Anabela Barcelos, Patricia Pinto, Fátima Godinho, Margarida Cruz, Elsa Vieira-Sousa, Rui André Santos, Sara Rabiais, Jorge Félix, João Eurico Fonseca, Henrique Guedes-Pinto, Matthew A. Brown, Jaime C. Branco, A. F. Mourão, A. A. De Matos, C. RibeiroF. M. Pimentel-Santos, J. Bravo Pimentão, M. Mateus, P. Nero, P. Araújo, S. Falcão, T. L. Pinto, W. Castelão, E. Vieira De Sousa, J. Caetano-Lopes, J. E. Fonseca, C. Silva, E. Simões, H. Madeira, H. Santos, J. Vaz Patto, J. Ferreira, M. Micaelo, M. J. Mediavilla, M. Sousa, P. Soares Branco, F. Godinho, J. Canas Da Silva, S. Garcês, V. Tavares, A. Ribeiro, D. Araújo, J. A. Costa, L. Costa, M. C. Afonso, M. Bogas, S. Alcino, P. Pinto, A. R. Cravo, G. Sequeira, R. A. Santos, A. Barcelos, I. Cunha, M. Cruz

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Abstract

The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.

Original language	English
Pages (from-to)	447-454
Number of pages	8
Journal	Clinical Rheumatology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s10067-011-1854-7
Publication status	Published - 1 Mar 2012
Externally published	Yes

Keywords

Ankylosing spondylitis
Charts
Epidemiology

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10.1007/s10067-011-1854-7

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Pimentel-Santos, F. M., Mourão, A. F., Ribeiro, C., Costa, J., Santos, H., Barcelos, A., Pinto, P., Godinho, F., Cruz, M., Vieira-Sousa, E., Santos, R. A., Rabiais, S., Félix, J., Fonseca, J. E., Guedes-Pinto, H., Brown, M. A., Branco, J. C., Mourão, A. F., De Matos, A. A., ... Cruz, M. (2012). Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts. Clinical Rheumatology, 31(3), 447-454. https://doi.org/10.1007/s10067-011-1854-7

@article{2c536981f46f414598a1b14993049a29,

title = "Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts",

abstract = "The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.",

keywords = "Ankylosing spondylitis, Charts, Epidemiology",

author = "Pimentel-Santos, {Fernando M.} and Mour{\~a}o, {Ana Filipa} and C{\'e}lia Ribeiro and Jos{\'e} Costa and Helena Santos and Anabela Barcelos and Patricia Pinto and F{\'a}tima Godinho and Margarida Cruz and Elsa Vieira-Sousa and Santos, {Rui Andr{\'e}} and Sara Rabiais and Jorge F{\'e}lix and Fonseca, {Jo{\~a}o Eurico} and Henrique Guedes-Pinto and Brown, {Matthew A.} and Branco, {Jaime C.} and Mour{\~a}o, {A. F.} and {De Matos}, {A. A.} and C. Ribeiro and Pimentel-Santos, {F. M.} and {Bravo Piment{\~a}o}, J. and M. Mateus and P. Nero and P. Ara{\'u}jo and S. Falc{\~a}o and Pinto, {T. L.} and W. Castel{\~a}o and {Vieira De Sousa}, E. and J. Caetano-Lopes and Fonseca, {J. E.} and C. Silva and E. Sim{\~o}es and H. Madeira and H. Santos and {Vaz Patto}, J. and J. Ferreira and M. Micaelo and Mediavilla, {M. J.} and M. Sousa and {Soares Branco}, P. and F. Godinho and {Canas Da Silva}, J. and S. Garc{\^e}s and V. Tavares and A. Ribeiro and D. Ara{\'u}jo and Costa, {J. A.} and L. Costa and Afonso, {M. C.} and M. Bogas and S. Alcino and P. Pinto and Cravo, {A. R.} and G. Sequeira and Santos, {R. A.} and A. Barcelos and I. Cunha and M. Cruz",

year = "2012",

month = mar,

day = "1",

doi = "10.1007/s10067-011-1854-7",

language = "English",

volume = "31",

pages = "447--454",

journal = "Clinical Rheumatology",

issn = "0770-3198",

publisher = "Springer London",

number = "3",

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Pimentel-Santos, FM, Mourão, AF, Ribeiro, C, Costa, J, Santos, H, Barcelos, A, Pinto, P, Godinho, F, Cruz, M, Vieira-Sousa, E, Santos, RA, Rabiais, S, Félix, J, Fonseca, JE, Guedes-Pinto, H, Brown, MA, Branco, JC, Mourão, AF, De Matos, AA, Ribeiro, C, Pimentel-Santos, FM, Bravo Pimentão, J, Mateus, M, Nero, P, Araújo, P, Falcão, S, Pinto, TL, Castelão, W, Vieira De Sousa, E, Caetano-Lopes, J, Fonseca, JE, Silva, C, Simões, E, Madeira, H, Santos, H, Vaz Patto, J, Ferreira, J, Micaelo, M, Mediavilla, MJ, Sousa, M, Soares Branco, P, Godinho, F, Canas Da Silva, J, Garcês, S, Tavares, V, Ribeiro, A, Araújo, D, Costa, JA, Costa, L, Afonso, MC, Bogas, M, Alcino, S, Pinto, P, Cravo, AR, Sequeira, G, Santos, RA, Barcelos, A, Cunha, I & Cruz, M 2012, 'Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts', Clinical Rheumatology, vol. 31, no. 3, pp. 447-454. https://doi.org/10.1007/s10067-011-1854-7

TY - JOUR

T1 - Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

AU - Pimentel-Santos, Fernando M.

AU - Mourão, Ana Filipa

AU - Ribeiro, Célia

AU - Costa, José

AU - Santos, Helena

AU - Barcelos, Anabela

AU - Pinto, Patricia

AU - Godinho, Fátima

AU - Cruz, Margarida

AU - Vieira-Sousa, Elsa

AU - Santos, Rui André

AU - Rabiais, Sara

AU - Félix, Jorge

AU - Fonseca, João Eurico

AU - Guedes-Pinto, Henrique

AU - Brown, Matthew A.

AU - Branco, Jaime C.

AU - Mourão, A. F.

AU - De Matos, A. A.

AU - Ribeiro, C.

AU - Pimentel-Santos, F. M.

AU - Bravo Pimentão, J.

AU - Mateus, M.

AU - Nero, P.

AU - Araújo, P.

AU - Falcão, S.

AU - Pinto, T. L.

AU - Castelão, W.

AU - Vieira De Sousa, E.

AU - Caetano-Lopes, J.

AU - Fonseca, J. E.

AU - Silva, C.

AU - Simões, E.

AU - Madeira, H.

AU - Santos, H.

AU - Vaz Patto, J.

AU - Ferreira, J.

AU - Micaelo, M.

AU - Mediavilla, M. J.

AU - Sousa, M.

AU - Soares Branco, P.

AU - Godinho, F.

AU - Canas Da Silva, J.

AU - Garcês, S.

AU - Tavares, V.

AU - Ribeiro, A.

AU - Araújo, D.

AU - Costa, J. A.

AU - Costa, L.

AU - Afonso, M. C.

AU - Bogas, M.

AU - Alcino, S.

AU - Pinto, P.

AU - Cravo, A. R.

AU - Sequeira, G.

AU - Santos, R. A.

AU - Barcelos, A.

AU - Cunha, I.

AU - Cruz, M.

PY - 2012/3/1

Y1 - 2012/3/1

N2 - The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.

AB - The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.

KW - Ankylosing spondylitis

KW - Charts

KW - Epidemiology

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U2 - 10.1007/s10067-011-1854-7

DO - 10.1007/s10067-011-1854-7

M3 - Article

AN - SCOPUS:84859787452

SN - 0770-3198

VL - 31

SP - 447

EP - 454

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 3

ER -

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

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Keywords

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