Structure and function of human matrix metalloproteinases

Helena Laronha; Jorge Caldeira

doi:10.3390/cells9051076

Structure and function of human matrix metalloproteinases

Helena Laronha, Jorge Caldeira

Research output: Contribution to journal › Review article › peer-review

320 Citations (Scopus)

Abstract

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

Original language	English
Article number	1076
Journal	Cells
Volume	9
Issue number	5
DOIs	https://doi.org/10.3390/cells9051076
Publication status	Published - May 2020

Keywords

Collagen
Matrix metalloproteinases
TIMP

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10.3390/cells9051076

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abstract = "The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.",

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AB - The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

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KW - TIMP

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Structure and function of human matrix metalloproteinases

Abstract

Keywords

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