Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Eduarda M.P. Silva, Francesca Giuntini, Maria A.F. Faustino, João P.C. Tomé, Maria G.P.M.S. Neves, Augusto C. Tomé, Artur M.S. Silva, Maria G. Santana-Marques, António J. Ferrer-Correia, José A.S. Cavaleiro, Maria F. Caeiro, Ricardo R. Duarte, Sabina A.P. Tavares, Inês N. Pegado, Bruno D'Almeida, António P.A. De Matos, Maria L. Valdeira

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

An easy route to cationic β-vinyl substituted meso- tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.

Original languageEnglish
Pages (from-to)3333-3337
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number14
DOIs
Publication statusPublished - 15 Jul 2005
Externally publishedYes

Keywords

  • Aldol condensation
  • HSV-1
  • Herpesviruses
  • Porphyrins

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