TY - JOUR
T1 - The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis
T2 - a systematic review and metaanalysis
AU - da Costa, Rodrigo Moreira Bringel
AU - Poluha, Rodrigo Lorenzi
AU - De la Torre Canales, Giancarlo
AU - Junior, Joel Ferreira Santiago
AU - Conti, Paulo Cesar Rodrigues
AU - Neppelenbroek, Karin Hermana
AU - Porto, Vinicius Carvalho
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Objective: To evaluate the effectiveness of microwave disinfection in treating Candida-associated denture stomatitis (CADS). Materials and methods: The PubMed/MEDLINE, Embase, and Scopus databases were searched for reports on randomized clinical trials (RCTs) published in English until May 2020 (PROSPERO CRD42020192062) that evaluated the treatment of CADS by using microwave disinfection. The main outcomes were the improvement of clinical signs and/or the decrease in the residual yeast present on the dentures and palatal mucosa. The mean differences, standard deviations, risk ratio, and 95% confidence interval were calculated by using the random-effects model. Heterogeneity was assessed by using Cochran’s Q test and I2 values. The level of significance was set at α = 0.05. Results: Five RCTs with 245 participants were included. The descriptive investigations demonstrated that microwave disinfection was as effective (p > 0.05) as 0.2% chlorhexidine, 0.02% sodium hypochlorite, and topical nystatin (100.000 IU/mL), and was superior to topical miconazole in treating CADS. The metaanalysis did not show a statistical difference between microwave disinfection and nystatin (100.000 IU/mL) treatment in terms of mycological counts, cure, and recurrence rates (p > 0.05). Conclusion: Microwave disinfection showed comparable results with those of conventional therapies for treating CADS. In addition, treatment with 650 W for 3 min once a week for 14 days had better cost-effect results, indicating both the prevention and treatment of CADS. Clinical relevance: Our findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality.
AB - Objective: To evaluate the effectiveness of microwave disinfection in treating Candida-associated denture stomatitis (CADS). Materials and methods: The PubMed/MEDLINE, Embase, and Scopus databases were searched for reports on randomized clinical trials (RCTs) published in English until May 2020 (PROSPERO CRD42020192062) that evaluated the treatment of CADS by using microwave disinfection. The main outcomes were the improvement of clinical signs and/or the decrease in the residual yeast present on the dentures and palatal mucosa. The mean differences, standard deviations, risk ratio, and 95% confidence interval were calculated by using the random-effects model. Heterogeneity was assessed by using Cochran’s Q test and I2 values. The level of significance was set at α = 0.05. Results: Five RCTs with 245 participants were included. The descriptive investigations demonstrated that microwave disinfection was as effective (p > 0.05) as 0.2% chlorhexidine, 0.02% sodium hypochlorite, and topical nystatin (100.000 IU/mL), and was superior to topical miconazole in treating CADS. The metaanalysis did not show a statistical difference between microwave disinfection and nystatin (100.000 IU/mL) treatment in terms of mycological counts, cure, and recurrence rates (p > 0.05). Conclusion: Microwave disinfection showed comparable results with those of conventional therapies for treating CADS. In addition, treatment with 650 W for 3 min once a week for 14 days had better cost-effect results, indicating both the prevention and treatment of CADS. Clinical relevance: Our findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality.
KW - Denture stomatitis
KW - Metaanalysis
KW - Microwaves
KW - Randomized controlled trial
KW - Systematic review
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85091403438&partnerID=8YFLogxK
U2 - 10.1007/s00784-020-03599-5
DO - 10.1007/s00784-020-03599-5
M3 - Review article
C2 - 32974776
AN - SCOPUS:85091403438
SN - 1432-6981
VL - 24
SP - 3821
EP - 3832
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 11
ER -