TY - JOUR
T1 - The exclusive presence of the chronic pulmonary disease could be more important in affecting autonomic cardiac modulation than the severity of airflow obstruction
T2 - Analysis using heart rate variability
AU - Ricci-Vitor, Ana Laura
AU - Marques Vanderlei, Luiz Carlos
AU - dos Santos, Ana Alice Soares
AU - Vanzella, Lais Manata
AU - Destro Christofaro, Diego Giulliano
AU - de Abreu, Luiz Carlos
AU - Cipulo Ramos, Ercy Mara
AU - de Godoy, Moacir Fernandes
AU - Filho, Celso Ferreira
AU - Ferreira, Celso
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - The autonomic nervous system regulates the caliber of the airways, blood flow, secretion production, modulates the inflammatory response and modulates airway responses to inflammation. Despite this, some intrinsic features could be more important in affecting autonomic modulation than the airflow severity. This study aimed to analyze the effects of chronic obstructive pulmonary disease (COPD) on autonomic modulation through heart rate variability (HRV) and its relationship with airflow severity. Outpatients with COPD (n = 30) and a control group (n = 26) were evaluated. The main outcome measures were anthropometry, spirometry and HRV. The presence of COPD had a large effect on autonomic modulation, demonstrated by a significant reduction in 6 out of 12 HRV indices according to the comparisons between the COPD groups (high and low severity) and the control group through HRV indices (rMSSD: 13.5 ± 7.3 vs. 10.4 ± 6.3 vs. 20.7 ± 7.1 ms; SDNN: 22.0 ± 11.2 vs. 17.1 ± 8.0 vs. 33.6 ± 13.8 ms; SD1: 9.6 ± 5.2 vs. 7.4 ± 4.5 vs. 14.6 ± 5.0 ms; SD2: 29.5 ± 15.2 vs. 22.9 ± 10.7 vs. 44.8 ± 20.0 ms). However, the severity of COPD presented no significant differences even when considering age, sex and body mass index (BMI). This study suggests that the presence of COPD could be more important in affecting HRV than the severity of airflow obstruction, independent of the sex, age or BMI.
AB - The autonomic nervous system regulates the caliber of the airways, blood flow, secretion production, modulates the inflammatory response and modulates airway responses to inflammation. Despite this, some intrinsic features could be more important in affecting autonomic modulation than the airflow severity. This study aimed to analyze the effects of chronic obstructive pulmonary disease (COPD) on autonomic modulation through heart rate variability (HRV) and its relationship with airflow severity. Outpatients with COPD (n = 30) and a control group (n = 26) were evaluated. The main outcome measures were anthropometry, spirometry and HRV. The presence of COPD had a large effect on autonomic modulation, demonstrated by a significant reduction in 6 out of 12 HRV indices according to the comparisons between the COPD groups (high and low severity) and the control group through HRV indices (rMSSD: 13.5 ± 7.3 vs. 10.4 ± 6.3 vs. 20.7 ± 7.1 ms; SDNN: 22.0 ± 11.2 vs. 17.1 ± 8.0 vs. 33.6 ± 13.8 ms; SD1: 9.6 ± 5.2 vs. 7.4 ± 4.5 vs. 14.6 ± 5.0 ms; SD2: 29.5 ± 15.2 vs. 22.9 ± 10.7 vs. 44.8 ± 20.0 ms). However, the severity of COPD presented no significant differences even when considering age, sex and body mass index (BMI). This study suggests that the presence of COPD could be more important in affecting HRV than the severity of airflow obstruction, independent of the sex, age or BMI.
KW - Autonomic nervous system
KW - Chronic obstructive pulmonary disease
KW - Heart rate
KW - Heart rate variability
KW - Respiratory disease
KW - Severity of illness index
UR - http://www.scopus.com/inward/record.url?scp=85041471192&partnerID=8YFLogxK
U2 - 10.1016/j.bspc.2018.01.004
DO - 10.1016/j.bspc.2018.01.004
M3 - Article
AN - SCOPUS:85041471192
SN - 1746-8094
VL - 42
SP - 101
EP - 106
JO - Biomedical Signal Processing and Control
JF - Biomedical Signal Processing and Control
ER -
