The mercapturomic profile of health and non-communicable diseases

Clara Gonçalves-Dias; Judit Morello; Valdir Semedo; M. João Correia; Nuno R. Coelho; Emilia C. Monteiro; Alexandra M.M. Antunes; Sofia A. Pereira

doi:10.3390/ht8020010

The mercapturomic profile of health and non-communicable diseases

Clara Gonçalves-Dias, Judit Morello, Valdir Semedo, M. João Correia, Nuno R. Coelho, Emilia C. Monteiro, Alexandra M.M. Antunes, Sofia A. Pereira

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

Original language	English
Article number	10
Journal	High-Throughput
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/ht8020010
Publication status	Published - Jun 2019
Externally published	Yes

Keywords

Biomarkers
Chronic inflammation
Cysteine-S-conjugates
Cysteinyl-leukotrienes
Disulfides
Dopamine
Estrogen
Mercapturate pathway
Metabolomics
N-acetyl-transferase 8

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ht8020010

Cite this

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title = "The mercapturomic profile of health and non-communicable diseases",

abstract = "The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.",

keywords = "Biomarkers, Chronic inflammation, Cysteine-S-conjugates, Cysteinyl-leukotrienes, Disulfides, Dopamine, Estrogen, Mercapturate pathway, Metabolomics, N-acetyl-transferase 8",

author = "Clara Gon{\c c}alves-Dias and Judit Morello and Valdir Semedo and Correia, {M. Jo{\~a}o} and Coelho, {Nuno R.} and Monteiro, {Emilia C.} and Antunes, {Alexandra M.M.} and Pereira, {Sofia A.}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jun,

doi = "10.3390/ht8020010",

language = "English",

volume = "8",

journal = "High-Throughput",

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AU - Gonçalves-Dias, Clara

AU - Morello, Judit

AU - Semedo, Valdir

AU - Correia, M. João

AU - Coelho, Nuno R.

AU - Monteiro, Emilia C.

AU - Antunes, Alexandra M.M.

AU - Pereira, Sofia A.

PY - 2019/6

Y1 - 2019/6

N2 - The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

AB - The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

KW - Biomarkers

KW - Chronic inflammation

KW - Cysteine-S-conjugates

KW - Cysteinyl-leukotrienes

KW - Disulfides

KW - Dopamine

KW - Estrogen

KW - Mercapturate pathway

KW - Metabolomics

KW - N-acetyl-transferase 8

UR - http://www.scopus.com/inward/record.url?scp=85067895174&partnerID=8YFLogxK

U2 - 10.3390/ht8020010

DO - 10.3390/ht8020010

M3 - Review article

AN - SCOPUS:85067895174

SN - 2571-5135

VL - 8

JO - High-Throughput

JF - High-Throughput

IS - 2

M1 - 10

ER -

The mercapturomic profile of health and non-communicable diseases

Abstract

Keywords

UN SDGs

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