TY - CHAP
T1 - The Role of Activation-Induced Deaminase in Antibody Diversification and Chromosome Translocations
AU - Ramiro, Almudena
AU - San-Martin, Bernardo Reina
AU - McBride, Kevin
AU - Jankovic, Mila
AU - Barreto, Vasco
AU - Nussenzweig, André
AU - Nussenzweig, Michel C.
PY - 2007
Y1 - 2007
N2 - Although B and T lymphocytes are similar in many respects including diversification of their antigen receptor genes by V(D)J recombination, 95% of all lymphomas diagnosed in the western world are of B-cell origin. Many of these are derived from mature B cells [Kuppers, R. (2005). Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251-262] and display hallmark chromosome translocations involving immunoglobulin genes and a proto-oncogene partner whose expression becomes deregulated as a result of the translocation reaction [Kuppers, R. (2005). Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251-262; Kuppers, R., and Dalla-Favera, R. (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594]. These translocations are essential to the etiology of B-cell neoplasms. Here we will review how the B-cell specific molecular events required for immunoglobulin class switch recombination are initiated and how they contribute to chromosome translocations in vivo.
AB - Although B and T lymphocytes are similar in many respects including diversification of their antigen receptor genes by V(D)J recombination, 95% of all lymphomas diagnosed in the western world are of B-cell origin. Many of these are derived from mature B cells [Kuppers, R. (2005). Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251-262] and display hallmark chromosome translocations involving immunoglobulin genes and a proto-oncogene partner whose expression becomes deregulated as a result of the translocation reaction [Kuppers, R. (2005). Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251-262; Kuppers, R., and Dalla-Favera, R. (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594]. These translocations are essential to the etiology of B-cell neoplasms. Here we will review how the B-cell specific molecular events required for immunoglobulin class switch recombination are initiated and how they contribute to chromosome translocations in vivo.
UR - http://www.scopus.com/inward/record.url?scp=34249793250&partnerID=8YFLogxK
U2 - 10.1016/S0065-2776(06)94003-6
DO - 10.1016/S0065-2776(06)94003-6
M3 - Chapter
C2 - 17560272
AN - SCOPUS:34249793250
SN - 0123737060
SN - 9780123737069
T3 - Advances in Immunology
SP - 75
EP - 107
BT - AID for Immunoglobulin Diversity
A2 - Alt, Frederick
A2 - Honjo, Tasuku
ER -