TY - JOUR
T1 - Use of a new dual-antigen enzyme-linked immunosorbent assay to detect and characterize the human antibody response to the human immunodeficiency virus type 2 envelope gp125 and gp36 glycoproteins
AU - Marcelino, José Maria
AU - Barroso, Helena
AU - Gonçalves, Fátima
AU - Silva, Sofia Marques
AU - Novo, Carlos
AU - Gomes, Perpétua
AU - Camacho, Ricardo
AU - Taveira, Nuno
PY - 2006/2
Y1 - 2006/2
N2 - A dual-antigen enzyme-linked immunosorbent assay specific for human immunodeficiency virus type 2 (HIV-2) envelope proteins, ELISA-HIV2, was developed with two new recombinant polypeptides, rpC2-C3 and rgp36, derived from the HIV-2 envelope. The diagnostic performance was determined with HIV-2, HIV-1, and HIV-1/2 samples. Both polypeptides showed 100% specificity. Clinical sensitivity was 100% for rgp36 and 93.4% for rpC2-C3. ELISA-HIV2 may be used for the specific diagnosis and confirmation of HIV-2 infection.
AB - A dual-antigen enzyme-linked immunosorbent assay specific for human immunodeficiency virus type 2 (HIV-2) envelope proteins, ELISA-HIV2, was developed with two new recombinant polypeptides, rpC2-C3 and rgp36, derived from the HIV-2 envelope. The diagnostic performance was determined with HIV-2, HIV-1, and HIV-1/2 samples. Both polypeptides showed 100% specificity. Clinical sensitivity was 100% for rgp36 and 93.4% for rpC2-C3. ELISA-HIV2 may be used for the specific diagnosis and confirmation of HIV-2 infection.
UR - http://www.scopus.com/inward/record.url?scp=32344453650&partnerID=8YFLogxK
U2 - 10.1128/JCM.44.2.607-611.2006
DO - 10.1128/JCM.44.2.607-611.2006
M3 - Article
C2 - 16455923
AN - SCOPUS:32344453650
SN - 0095-1137
VL - 44
SP - 607
EP - 611
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 2
ER -
