Whither vaccines?

Charlene M.C. Rodrigues; Marta V. Pinto; Manish Sadarangani; Stanley A. Plotkin

doi:10.1016/S0163-4453(17)30184-6

Whither vaccines?

Charlene M.C. Rodrigues, Marta V. Pinto, Manish Sadarangani, Stanley A. Plotkin

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas.

Original language	English
Pages (from-to)	S2-S9
Journal	Journal of Infection
Volume	74
DOIs	https://doi.org/10.1016/S0163-4453(17)30184-6
Publication status	Published - Jun 2017
Externally published	Yes

Keywords

CMV
Dengue
HIV
Host immunity
Influenza
Pertussis
RSV
Rotavirus
Structural biology
Vaccinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0163-4453(17)30184-6

Cite this

@article{38fd9b3eb62740f2b70503a7bce445ce,

title = "Whither vaccines?",

abstract = "Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas.",

keywords = "CMV, Dengue, HIV, Host immunity, Influenza, Pertussis, RSV, Rotavirus, Structural biology, Vaccinology",

author = "Rodrigues, {Charlene M.C.} and Pinto, {Marta V.} and Manish Sadarangani and Plotkin, {Stanley A.}",

note = "Publisher Copyright: {\textcopyright} 2017 The British Infection Association",

year = "2017",

month = jun,

doi = "10.1016/S0163-4453(17)30184-6",

language = "English",

volume = "74",

pages = "S2--S9",

journal = "Journal of Infection",