EFFECTS OF TRANSCRANIAL ELECTRICAL STIMULATION BY CONTINUOUS CURRENT ON THE RIGHT AND LEFT DORSOLATERAL PREFRONTAL CORTEX ASSOCIATED OR NOT WITH NON-INVASIVE VAGUUS NERVE STIMULATION IN ADULT INDIVIDUALS WITH CHRONIC STRESS

GOALS
Several studies have shown positive and promising effects of non-invasive neuromodulation (tDCS and tVNS) in the treatment of various neuropsychiatric disorders, but there is a need for more research in relation to some disorders, such as stress. The hypothesis is to verify whether different non-invasive neuromodulation techniques are effective in reducing the intensity of stress symptoms.
Main goal
• Evaluate the effects of non-invasive neuromodulation in adult individuals with chronic stress.
Specific objectives
• Verify whether transcranial direct current electrical stimulation in the right (anodal F4) and left (cathodal F3) dorsolateral prefrontal cortex is effective in reducing the intensity of symptoms measured by the Inventory of Stress Symptoms for Adults (ISSL).
• Verify whether transcranial direct current electrical stimulation of the right (anodal F4) and left (cathodal F3) dorsolateral prefrontal cortex is effective in reducing the intensity of symptoms measured by the stress perception scale.
• Verify whether transcranial direct current electrical stimulation in the right (anodal F4) and left (cathodal F3) dorsolateral cortex associated with tVNS is effective in reducing the intensity of symptoms measured by the Stress Symptom Inventory for adults.
• Verify whether transcranial direct current electrical stimulation in the right (anodal F4) and left (cathodal F3) dorsolateral prefrontal cortex associated with tVNS is effective in reducing the intensity of symptoms measured by the stress perception scale.
• Verify whether transcranial direct current electrical stimulation of the right (anodal F4) and left (cathodal F3) dorsolateral prefrontal cortex is effective in improving sleep in individuals with stress symptoms in adults.
• Verify whether transcranial direct current electrical stimulation of the right (anodal F4) and left (cathodal F3) prefrontal cortex associated with tVNS is effective in improving sleep in individuals with adult stress symptoms.

Stress is a disorder with a major impact on the lives of those affected. Pharmacological treatment has limitations, justifying the search for non-pharmacological interventions. tDCS is a technique that modulates neuronal excitability and has shown promising results in several disorders.
Psychological stress affects a wide spectrum of brain functions and poses risks for many mental disorders. However, there is a lack of effective therapies to alleviate or reverse its harmful effects.
Considering that the pathophysiology of stress involves brain fields such as: prefrontal cortex, central amygdaloid nucleus, amygdala, medial amygdaloid nucleus and ventral hippocampus, making the condition complex, therefore there is a need for studies evaluating the effects of this intervention, we therefore seek to contribute to the clarification regarding the role of tDCS and tVNS in stress management.

in progress