Resumo
Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal ( + +) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol : phospholipid : galactolipid and the cerebroside : sulfatide molar ratios and also the phospholipid composition were normal. 2′, 3′-Cyclic nucleotide 3′-phosphohydrolase (CNP) and UDP-galactose ceramide galactosyltransferase (CGalT) enzymatic activities were normal, and 3′-phosphoadenosine 5′-phosphosulfate (PAPS) : cerebroside sulfotransferase (CST) was only slightly decreased. Cholesterol esters were not present in the mutant. These results indicate that brain myelination is affected in obese mutant mice.
Idioma original | ???core.languages.en_GB??? |
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Páginas (de-até) | 233-244 |
Número de páginas | 12 |
Revista | Journal of the Neurological Sciences |
Volume | 68 |
Número de emissão | 2-3 |
DOIs | |
Estado da publicação | ???researchoutput.status.published??? - mai. 1985 |
Publicado externamente | Sim |