Cardiometabolic risk, inflammation, and neurodegenerative disorder

Inflammation has been recognized as an important character in the underlying mechanisms leading to the development of various types of neurodegenerative disorders. In this sense, both inflammation of the nervous system itself and systemic inflammation act in the complex pathophysiology of these neurological diseases. The nervous system does not play a passive role in the complexity of these mechanisms and can itself be responsible for perpetuating pro-inflammatory stimuli – it is today recognized the important role that specific brain areas play in the so-called metabolic inflammation. This dialectical relationship will be the focus of this chapter.