TY - GEN
T1 - Characterization of Plasmonic Effects in AuNP+rGO Composite as a Sensing Layer for a Low-cost Lab-on-chip Biosensor
AU - Fantoni, Alessandro
AU - Stojkovic, Vladan
AU - Fernandes, Miguel
AU - Louro, Paula
AU - Vieira, Manuela
AU - Alegria, Elisabete C.B.A.
AU - Ribeiro, Ana P.C.
AU - Carvalho, Ana
AU - Almeida, M. Gabriela
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/6
Y1 - 2019/6
N2 - This work deals with the production of a low-cost disposable biosensor for point of care applications. The proposed sensor is a plasmonic structure based on the Localized Surface Plasmon Resonance (LSPR) interaction of metal nanoparticles (MNPs), embedded into a matrix of reduced Graphene Oxide (rGO). After proper functionalization with selective antibodies (Ab), the efficiency of light extinction is controlled by slight changes of the refractive coefficient induced by the concentration of biomarkers trapped by the antibodies on the sensor surface. This work reports a study about the applicability of rGO as a support for gold nanoparticles (AuNPs) for preparing the functionalized LSPR sensing layer. AuNPs are prepared with an economic and eco-friendly method using phytochemicals present in tea extract at room temperature, while a modified Hummer's method is used to synthesize rGO. The resulting AuNPs-rGO composites are studied in terms of UV-VIS spectroscopy spectral light transmission and plasmonic resonance. The overall analysis is supported by simulation results, obtained by Mie analysis, about the LSPR effect in AuNPs-rGO and its dependence on the biomarker concentration.
AB - This work deals with the production of a low-cost disposable biosensor for point of care applications. The proposed sensor is a plasmonic structure based on the Localized Surface Plasmon Resonance (LSPR) interaction of metal nanoparticles (MNPs), embedded into a matrix of reduced Graphene Oxide (rGO). After proper functionalization with selective antibodies (Ab), the efficiency of light extinction is controlled by slight changes of the refractive coefficient induced by the concentration of biomarkers trapped by the antibodies on the sensor surface. This work reports a study about the applicability of rGO as a support for gold nanoparticles (AuNPs) for preparing the functionalized LSPR sensing layer. AuNPs are prepared with an economic and eco-friendly method using phytochemicals present in tea extract at room temperature, while a modified Hummer's method is used to synthesize rGO. The resulting AuNPs-rGO composites are studied in terms of UV-VIS spectroscopy spectral light transmission and plasmonic resonance. The overall analysis is supported by simulation results, obtained by Mie analysis, about the LSPR effect in AuNPs-rGO and its dependence on the biomarker concentration.
UR - https://www.scopus.com/pages/publications/85081998022
U2 - 10.1109/PIERS-Spring46901.2019.9017299
DO - 10.1109/PIERS-Spring46901.2019.9017299
M3 - Conference contribution
AN - SCOPUS:85081998022
T3 - Progress in Electromagnetics Research Symposium
SP - 4180
EP - 4186
BT - 2019 PhotonIcs and Electromagnetics Research Symposium - Spring, PIERS-Spring 2019 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2019 PhotonIcs and Electromagnetics Research Symposium - Spring, PIERS-Spring 2019
Y2 - 17 June 2019 through 20 June 2019
ER -