Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases

Mara Soares da Silva; Eva R. Vão; Márcio Temtem; Luís Mafra; Jorge Caldeira; Ana Aguiar-Ricardo; Teresa Casimiro

doi:10.1016/j.bios.2009.12.023

Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases

Mara Soares da Silva
, Eva R. Vão
, Márcio Temtem
, Luís Mafra
, Jorge Caldeira
, Ana Aguiar-Ricardo
, Teresa Casimiro

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

66 Citações (Scopus)

Resumo

Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO₂), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	1742-1747
Número de páginas	6
Revista	Biosensors and Bioelectronics
Volume	25
Número de emissão	7
DOIs	https://doi.org/10.1016/j.bios.2009.12.023
Estado da publicação	???researchoutput.status.published??? - 15 mar. 2010

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10.1016/j.bios.2009.12.023

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da Silva, M. S., Vão, E. R., Temtem, M., Mafra, L., Caldeira, J., Aguiar-Ricardo, A., & Casimiro, T. (2010). Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases. Biosensors and Bioelectronics, 25(7), 1742-1747. https://doi.org/10.1016/j.bios.2009.12.023

@article{38e4d66f32fc4810aecef7d20f50801a,

title = "Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases",

abstract = "Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.",

keywords = "Enantiomeric separation, HPLC, MIP, Molecular imprinting, Supercritical fluid technology, Tryptophan",

author = "\{da Silva\}, \{Mara Soares\} and V{\~a}o, \{Eva R.\} and M{\'a}rcio Temtem and Lu{\'i}s Mafra and Jorge Caldeira and Ana Aguiar-Ricardo and Teresa Casimiro",

note = "Funding Information: The authors would like to thank Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia (FCT-Lisbon) for financial support through projects PTDC/QUI/66086/2006 and PTDC/CTM/70513/2006, and doctoral grant SFRH/BD/31085/2006 (M.S.S.), FEDER, FSE and POCTI. The Portuguese NMR Network is acknowledged for granting access to the NMR equipment. ",

year = "2010",

month = mar,

day = "15",

doi = "10.1016/j.bios.2009.12.023",

language = "English",

volume = "25",

pages = "1742--1747",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

publisher = "Elsevier Ltd.",

number = "7",

}

da Silva, MS, Vão, ER, Temtem, M, Mafra, L, Caldeira, J, Aguiar-Ricardo, A & Casimiro, T 2010, 'Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases', Biosensors and Bioelectronics, vol. 25, n.º 7, pp. 1742-1747. https://doi.org/10.1016/j.bios.2009.12.023

Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases. / da Silva, Mara Soares; Vão, Eva R.; Temtem, Márcio et al.
Em: Biosensors and Bioelectronics, Vol. 25, N.º 7, 15.03.2010, p. 1742-1747.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases

AU - da Silva, Mara Soares

AU - Vão, Eva R.

AU - Temtem, Márcio

AU - Mafra, Luís

AU - Caldeira, Jorge

AU - Aguiar-Ricardo, Ana

AU - Casimiro, Teresa

N1 - Funding Information: The authors would like to thank Fundação para a Ciência e Tecnologia (FCT-Lisbon) for financial support through projects PTDC/QUI/66086/2006 and PTDC/CTM/70513/2006, and doctoral grant SFRH/BD/31085/2006 (M.S.S.), FEDER, FSE and POCTI. The Portuguese NMR Network is acknowledged for granting access to the NMR equipment.

PY - 2010/3/15

Y1 - 2010/3/15

N2 - Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.

AB - Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.

KW - Enantiomeric separation

KW - HPLC

KW - MIP

KW - Molecular imprinting

KW - Supercritical fluid technology

KW - Tryptophan

UR - https://www.scopus.com/pages/publications/77952318346

U2 - 10.1016/j.bios.2009.12.023

DO - 10.1016/j.bios.2009.12.023

M3 - Article

C2 - 20096557

AN - SCOPUS:77952318346

SN - 0956-5663

VL - 25

SP - 1742

EP - 1747

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 7

ER -

Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases

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