“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

Ana Gomes; Lucinda J. Bessa; Patrícia Correia; Iva Fernandes; Ricardo Ferraz; Paula Gameiro; Cátia Teixeira; Paula Gomes

doi:10.3390/ijms21176174

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

Ana Gomes
, Lucinda J. Bessa
, Patrícia Correia
, Iva Fernandes
, Ricardo Ferraz
, Paula Gameiro
, Cátia Teixeira
, Paula Gomes

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

21 Citações (Scopus)

Resumo

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

Idioma original	???core.languages.en_GB???
Número do artigo	6174
Páginas (de-até)	1-11
Número de páginas	11
Revista	International Journal of Molecular Sciences
Volume	21
Número de emissão	17
DOIs	https://doi.org/10.3390/ijms21176174
Estado da publicação	???researchoutput.status.published??? - 1 set. 2020
Publicado externamente	Sim

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title = "“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability",

abstract = "A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide{\textquoteright}s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.",

keywords = "Antibacterial, Antibiofilm, Ionic liquid, Multidrug resistance, Peptide, Skin infections, Tyrosinase, Wound healing",

author = "Ana Gomes and Bessa, \{Lucinda J.\} and Patr{\'i}cia Correia and Iva Fernandes and Ricardo Ferraz and Paula Gameiro and C{\'a}tia Teixeira and Paula Gomes",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = sep,

day = "1",

doi = "10.3390/ijms21176174",

language = "English",

volume = "21",

pages = "1--11",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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}

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability. / Gomes, Ana; Bessa, Lucinda J.; Correia, Patrícia et al.
Em: International Journal of Molecular Sciences, Vol. 21, N.º 17, 6174, 01.09.2020, p. 1-11.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide

T2 - On the Route Towards Improved Stability

AU - Gomes, Ana

AU - Bessa, Lucinda J.

AU - Correia, Patrícia

AU - Fernandes, Iva

AU - Ferraz, Ricardo

AU - Gameiro, Paula

AU - Teixeira, Cátia

AU - Gomes, Paula

PY - 2020/9/1

Y1 - 2020/9/1

N2 - A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

AB - A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

KW - Antibacterial

KW - Antibiofilm

KW - Ionic liquid

KW - Multidrug resistance

KW - Peptide

KW - Skin infections

KW - Tyrosinase

KW - Wound healing

UR - https://www.scopus.com/pages/publications/85089842600

U2 - 10.3390/ijms21176174

DO - 10.3390/ijms21176174

M3 - Article

C2 - 32859111

AN - SCOPUS:85089842600

SN - 1661-6596

VL - 21

SP - 1

EP - 11

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 17

M1 - 6174

ER -

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

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