Controlled drug release from dental obturation cements

João Tiago, Ana Paula Serro, Maria Guilhermina Moutinho

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Resumo

The main purpose of this work is to investigate the release of antibiotics incorporated in dental obturation cements. It constitutes a first approach to the development of a type of drug delivery system with great interest and potential, that still is practically inexistent in the market. Several antibiotics and root canal sealers (RCS) were pretested through microbiological and dissolution tests, respectively in order to select the system(s) to study. Ampicillin was chosen to be incorporated in two commercial RCS, AH Plus® and EndoREZ®. The drug release kinetics was evaluated by high performance chromatography (HPLC) as a function of drug load and film thickness, and its microbiological efficacy after release was proven. For both sealers, ampicillin release occurred in the first few hours and depends on the drug load and film thickness. The relative amount released from EndoREZ® was higher, due to its higher hydrophilicity and porosity.

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Título da publicação do anfitrião2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012
DOIs
Estado da publicação???researchoutput.status.published??? - 2012
Publicado externamenteSim
Evento2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012 - Coimbra
Duração: 23 fev. 201225 fev. 2012

Série de publicação

Nome2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012

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???event.eventtypes.event.conference???2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012
País/TerritórioPortugal
CidadeCoimbra
Período23/02/1225/02/12

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