Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry

Raminta Zmuidinaite; Ray K. Iles; Ricardo J. Pais; Stephen A. Butler

doi:10.1016/B978-0-12-820050-6.00008-4

Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry

Raminta Zmuidinaite
, Ray K. Iles
, Ricardo J. Pais
, Stephen A. Butler

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontobookanthology.chapter??? › revisão de pares

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Primarily, the purpose of hCG detection has been the confirmation of pregnancy by analysis of urine or blood. However, the number of applications for which hCG or hCGβ has been used for diagnostic purposes has significantly grown over the years. Examples of such applications are the detection of hydatidiform mole, cancer, ectopic pregnancy, and fetal trisomies. The wide range of applications renders the accurate and precise detection and quantification of the molecule in various biological fluids necessary. Therefore, in this chapter, the quantification and detection of hCG and its variants using MALDI-ToF mass spectrometry will be discussed.

Idioma original	???core.languages.en_GB???
Título da publicação do anfitrião	100 Years of Human Chorionic Gonadotropin
Subtítulo da publicação do anfitrião	Reviews and New Perspectives
Editora	Elsevier
Páginas	75-85
Número de páginas	11
ISBN (eletrónico)	9780128200506
ISBN (impresso)	9780128216095
DOIs	https://doi.org/10.1016/B978-0-12-820050-6.00008-4
Estado da publicação	???researchoutput.status.published??? - 1 jan. 2020
Publicado externamente	Sim

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title = "Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry",

abstract = "Primarily, the purpose of hCG detection has been the confirmation of pregnancy by analysis of urine or blood. However, the number of applications for which hCG or hCGβ has been used for diagnostic purposes has significantly grown over the years. Examples of such applications are the detection of hydatidiform mole, cancer, ectopic pregnancy, and fetal trisomies. The wide range of applications renders the accurate and precise detection and quantification of the molecule in various biological fluids necessary. Therefore, in this chapter, the quantification and detection of hCG and its variants using MALDI-ToF mass spectrometry will be discussed.",

keywords = "Detection, Immunoassay, MALDI-ToF MS, Quantitation, hCG isoforms, hCGα, hCGβ, hCGβ core fragment",

author = "Raminta Zmuidinaite and Iles, \{Ray K.\} and Pais, \{Ricardo J.\} and Butler, \{Stephen A.\}",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-820050-6.00008-4",

language = "English",

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booktitle = "100 Years of Human Chorionic Gonadotropin",

publisher = "Elsevier",

address = "Netherlands",

}

Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry. / Zmuidinaite, Raminta; Iles, Ray K.; Pais, Ricardo J. et al.
100 Years of Human Chorionic Gonadotropin: Reviews and New Perspectives. Elsevier, 2020. p. 75-85.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontobookanthology.chapter??? › revisão de pares

TY - CHAP

T1 - Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry

AU - Zmuidinaite, Raminta

AU - Iles, Ray K.

AU - Pais, Ricardo J.

AU - Butler, Stephen A.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Primarily, the purpose of hCG detection has been the confirmation of pregnancy by analysis of urine or blood. However, the number of applications for which hCG or hCGβ has been used for diagnostic purposes has significantly grown over the years. Examples of such applications are the detection of hydatidiform mole, cancer, ectopic pregnancy, and fetal trisomies. The wide range of applications renders the accurate and precise detection and quantification of the molecule in various biological fluids necessary. Therefore, in this chapter, the quantification and detection of hCG and its variants using MALDI-ToF mass spectrometry will be discussed.

AB - Primarily, the purpose of hCG detection has been the confirmation of pregnancy by analysis of urine or blood. However, the number of applications for which hCG or hCGβ has been used for diagnostic purposes has significantly grown over the years. Examples of such applications are the detection of hydatidiform mole, cancer, ectopic pregnancy, and fetal trisomies. The wide range of applications renders the accurate and precise detection and quantification of the molecule in various biological fluids necessary. Therefore, in this chapter, the quantification and detection of hCG and its variants using MALDI-ToF mass spectrometry will be discussed.

KW - Detection

KW - Immunoassay

KW - MALDI-ToF MS

KW - Quantitation

KW - hCG isoforms

KW - hCGα

KW - hCGβ

KW - hCGβ core fragment

UR - https://www.scopus.com/pages/publications/85117712619

U2 - 10.1016/B978-0-12-820050-6.00008-4

DO - 10.1016/B978-0-12-820050-6.00008-4

M3 - Chapter

AN - SCOPUS:85117712619

SN - 9780128216095

SP - 75

EP - 85

BT - 100 Years of Human Chorionic Gonadotropin

PB - Elsevier

ER -

Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry

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