Dietary fiber and DMBA-induced rat mammary carcinomas

Resultado de pesquisa: ???type-name??????researchoutput.researchoutputtypes.contributiontojournal.article???revisão de pares

1 Citação (Scopus)

Resumo

Dietary fiber had been previously associated with breast cancer risk but some controversies remain on the role of insoluble fiber type. The aim of the present study was to evaluate the effect of a fiber rich food in an experimental model of mammary carcinogenesis. Animals from study groups received a fiber rich food and were compared with two control groups receiving standard food, two groups received the administration of a common carcinogen and histopathological and blood analysis were conducted. Only four tumors were found on group receiving fiber and the carcinogen against the thirty three tumors found on group receiving only the carcinogen and standard food. Additionally, blood cholesterol and triglycerides were significantly lower in this group (p<0.05). Glycaemia was also lower but without significance. The experimental results had shown a possible protective effect of fiber on mammary carcinomas possible due to carcinogen binding, weight-gain prevention and insulin sensitivity. Further studies should address the effect of the several fiber types on mammary carcinogenesis process.

Idioma original???core.languages.en_GB???
Páginas (de-até)289-299
Número de páginas11
RevistaInternational Journal of Cancer Research
Volume7
Número de emissão4
DOIs
Estado da publicação???researchoutput.status.published??? - 2011

Impressão digital

Mergulhe nos tópicos de investigação de “Dietary fiber and DMBA-induced rat mammary carcinomas“. Em conjunto formam uma impressão digital única.

Citar isto