Drug delivery systems for mouth wound healing

The oral cavity is a complex and vital part of the human anatomy, responsible for functions such as speech, taste, and immune defense. Due to its high exposure to various agents and intricate physiological and anatomical features, the oral mucosa is prone to numerous pathological conditions. Drug delivery systems offer a promising avenue for enhancing wound healing in the oral cavity by ensuring controlled drug release and targeted site-specific therapy. Recent advancements in this field include mucoadhesive systems, lipid-based formulations, microparticles, nanoparticles, hydrogels, and drug-eluting implants. These innovative systems have shown considerable advantages over current therapeutic approaches in in vitro and in vivo studies. However, their clinical application remains to be fully realized. Future clinical trials are expected to validate the safety and efficacy of these systems for patient use. Emerging technologies and innovative bioengineering hold significant potential for treating mouth wounds, including aphthous ulcers, oral mucositis, and periodontal disease.