Effects of large pressure amplitude low frequency noise in the parotid gland perivasculo-ductal connective tissue

Título traduzido da contribuição: Efeitos do ruído de baixa frequência de alta amplitude no tecido conjuntivo perivasculo-ductal da glândula parótida

Pedro Oliveira, José Brito, João Mendes, Jorge Da Fonseca, Artur Águas, José Martins dos Santos

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Resumo

Introduction: In tissues and organs exposed to large pressure amplitude low frequency noise fibrosis occurs in the absence of inflammatory signs, which is thought to be a protective response. In the parotid gland the perivasculo-ductal connective tissue surrounds arteries, veins and the ductal tree. Perivasculo-ductal connective tissue is believed to function as a mechanical stabilizer of the glandular tissue. Material and Methods: In order to quantify the proliferation of perivasculo-ductal connective tissue in large pressure amplitude low frequency noise-exposed rats we used sixty Wistar rats which were equally divided into 6 groups. One group kept in silence, and the remaining five exposed to continuous large pressure amplitude low frequency noise: g1-168h (1 week); g2-504h (3 weeks); g3-840h (5 weeks); g4-1512h (9 weeks); and g5-2184h (13 weeks). After exposure, parotid glands were removed and the perivasculo-ductal connective tissue area was measured in all groups. We applied ANOVA statistical analysis, using SPSS 13.0. Results: The global trend is an increase in the average perivasculo-ductal connective tissue areas, that develops linearly and significantly with large pressure amplitude low frequency noise exposure time (p < 0.001). Discussion: It has been suggested that the biological response to large pressure amplitude low frequency noise exposure is associated with the need to maintain structural integrity. The structural reinforcement would be achieved by increased perivasculo-ductal connective tissue. Conclusions: Hence, these results show that in response to large pressure amplitude low frequency noise exposure, rat parotid glands increase their perivasculo-ductal connective tissue.

Título traduzido da contribuiçãoEfeitos do ruído de baixa frequência de alta amplitude no tecido conjuntivo perivasculo-ductal da glândula parótida
Idioma original???core.languages.en_GB???
Páginas (de-até)237-242
Número de páginas6
RevistaActa Medica Portuguesa
Volume26
Número de emissão3
Estado da publicação???researchoutput.status.published??? - 2013

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