First description of a herpesvirus infection in genus Lepus

F. A. Abade dos Santos, M. Monteiro, A. Pinto, C. L. Carvalho, M. C. Peleteiro, P. Carvalho, P. Mendonça, T. Carvalho, M. D. Duarte

Resultado de pesquisa: ???type-name??????researchoutput.researchoutputtypes.contributiontojournal.article???revisão de pares

12 Citações (Scopus)

Resumo

During the necropsies of Iberian hares obtained in 2018/2019, along with signs of the nodular form of myxomatosis, other unexpected external lesions were also observed. Histopathology revealed nuclear inclusion bodies in stromal cells suggesting the additional presence of a nuclear replicating virus. Transmission electron microscopy further demonstrated the presence of herpesvirus particles in the tissues of affected hares. We confirmed the presence of herpesvirus in 13 MYXV-positive hares by PCR and sequencing analysis. Herpesvirus-DNA was also detected in seven healthy hares, suggesting its asymptomatic circulation. Phylogenetic analysis based on concatenated partial sequences of DNA polymerase gene and glycoprotein B gene enabled greater resolution than analysing the sequences individually. The hare’ virus was classified close to herpesviruses from rodents within the Rhadinovirus genus of the gammaherpesvirus subfamily. We propose to name this new virus Leporid gammaherpesvirus 5 (LeHV-5), according to the International Committee on Taxonomy of Viruses standards. The impact of herpesvirus infection on the reproduction and mortality of the Iberian hare is yet unknown but may aggravate the decline of wild populations caused by the recently emerged natural recombinant myxoma virus.

Idioma original???core.languages.en_GB???
Número do artigoe0231795
RevistaPLoS ONE
Volume15
Número de emissão4
DOIs
Estado da publicação???researchoutput.status.published??? - abr. 2020
Publicado externamenteSim

Impressão digital

Mergulhe nos tópicos de investigação de “First description of a herpesvirus infection in genus Lepus“. Em conjunto formam uma impressão digital única.

Citar isto