First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

Cátia Caneiras; Filipa Calisto; Gabriela Jorge da Silva; Luis Lito; José Melo-Cristino; Aida Duarte

doi:10.3390/antibiotics7040096

First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

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Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes bla_KPC-3, bla_TEM-1 and bla_SHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

Idioma original	???core.languages.en_GB???
Número do artigo	96
Revista	Antibiotics
Volume	7
Número de emissão	4
DOIs	https://doi.org/10.3390/antibiotics7040096
Estado da publicação	???researchoutput.status.published??? - dez. 2018
Publicado externamente	Sim

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title = "First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal",

abstract = "Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.",

keywords = "A. Baumannii, Antimicrobial resistance, Colistin, Gram-negative bacteria, K. Pneumoniae, KPC-3 carbapenemase, Tigecycline",

author = "C{\'a}tia Caneiras and Filipa Calisto and {da Silva}, {Gabriela Jorge} and Luis Lito and Jos{\'e} Melo-Cristino and Aida Duarte",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = dec,

doi = "10.3390/antibiotics7040096",

language = "English",

volume = "7",

journal = "Antibiotics",

issn = "2079-6382",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

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First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal. / Caneiras, Cátia; Calisto, Filipa; da Silva, Gabriela Jorge et al.
Em: Antibiotics, Vol. 7, N.º 4, 96, 12.2018.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

AU - Caneiras, Cátia

AU - Calisto, Filipa

AU - da Silva, Gabriela Jorge

AU - Lito, Luis

AU - Melo-Cristino, José

AU - Duarte, Aida

PY - 2018/12

Y1 - 2018/12

N2 - Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

AB - Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

KW - A. Baumannii

KW - Antimicrobial resistance

KW - Colistin

KW - Gram-negative bacteria

KW - K. Pneumoniae

KW - KPC-3 carbapenemase

KW - Tigecycline

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U2 - 10.3390/antibiotics7040096

DO - 10.3390/antibiotics7040096

M3 - Article

AN - SCOPUS:85057153523

SN - 2079-6382

VL - 7

JO - Antibiotics

JF - Antibiotics

IS - 4

M1 - 96

ER -

First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

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