First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast

Marta Oliveira; Maria João Rodrigues; Catarina Pereira; Rubens Lima do Monte Neto; Policarpo Ademar Santos Junior; Nuno da Rosa Neng; José Manuel Florêncio Nogueira; João Varela; Luísa Barreira; Luísa Custódio

doi:10.1080/14786419.2017.1326489

First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast

Marta Oliveira
, Maria João Rodrigues
, Catarina Pereira
, Rubens Lima do Monte Neto
, Policarpo Ademar Santos Junior
, Nuno da Rosa Neng
, José Manuel Florêncio Nogueira
, João Varela
, Luísa Barreira
, Luísa Custódio

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16 Citações (Scopus)

Resumo

This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	600-604
Número de páginas	5
Revista	Natural Product Research
Volume	32
Número de emissão	5
DOIs	https://doi.org/10.1080/14786419.2017.1326489
Estado da publicação	???researchoutput.status.published??? - 4 mar. 2018
Publicado externamente	Sim

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title = "First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast",

abstract = "This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.",

keywords = "Antiparasitic, Inula chritmoides, Leishmania infantum, Spergularia rubra, halophytes, neglected tropical diseases, visceral leishmaniasis",

author = "Marta Oliveira and \{Jo{\~a}o Rodrigues\}, Maria and Catarina Pereira and Neto, \{Rubens Lima do Monte\} and Junior, \{Policarpo Ademar Santos\} and Neng, \{Nuno da Rosa\} and Nogueira, \{Jos{\'e} Manuel Flor{\^e}ncio\} and Jo{\~a}o Varela and Lu{\'i}sa Barreira and Lu{\'i}sa Cust{\'o}dio",

note = "Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2018",

month = mar,

day = "4",

doi = "10.1080/14786419.2017.1326489",

language = "English",

volume = "32",

pages = "600--604",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. / Oliveira, Marta; João Rodrigues, Maria; Pereira, Catarina et al.
Em: Natural Product Research, Vol. 32, N.º 5, 04.03.2018, p. 600-604.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast

AU - Oliveira, Marta

AU - João Rodrigues, Maria

AU - Pereira, Catarina

AU - Neto, Rubens Lima do Monte

AU - Junior, Policarpo Ademar Santos

AU - Neng, Nuno da Rosa

AU - Nogueira, José Manuel Florêncio

AU - Varela, João

AU - Barreira, Luísa

AU - Custódio, Luísa

PY - 2018/3/4

Y1 - 2018/3/4

N2 - This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.

AB - This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.

KW - Antiparasitic

KW - Inula chritmoides

KW - Leishmania infantum

KW - Spergularia rubra

KW - halophytes

KW - neglected tropical diseases

KW - visceral leishmaniasis

UR - https://www.scopus.com/pages/publications/85019236575

U2 - 10.1080/14786419.2017.1326489

DO - 10.1080/14786419.2017.1326489

M3 - Article

C2 - 28494617

AN - SCOPUS:85019236575

SN - 1478-6419

VL - 32

SP - 600

EP - 604

JO - Natural Product Research

JF - Natural Product Research

IS - 5

ER -

First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast

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