Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Armando Sena, Gérard Rebel, Robert Bieth, Pierre Hubert, Albert Waksman

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21 Citações (Scopus)

Resumo

Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

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Páginas (de-até)290-296
Número de páginas7
RevistaBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume710
Número de emissão3
DOIs
Estado da publicação???researchoutput.status.published??? - 12 mar. 1982
Publicado externamenteSim

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