Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Armando Sena; Gérard Rebel; Robert Bieth; Pierre Hubert; Albert Waksman

doi:10.1016/0005-2760(82)90111-4

Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Armando Sena
, Gérard Rebel
, Robert Bieth
, Pierre Hubert
, Albert Waksman

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

21 Citações (Scopus)

Resumo

Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	290-296
Número de páginas	7
Revista	Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume	710
Número de emissão	3
DOIs	https://doi.org/10.1016/0005-2760(82)90111-4
Estado da publicação	???researchoutput.status.published??? - 12 mar. 1982
Publicado externamente	Sim

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@article{26e7adc907a64031b82dad534902a644,

title = "Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice",

abstract = "Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.",

keywords = "(Mouse), Cholesterol, Lipid composition, Obesity, Phosphatide fatty acid",

author = "Armando Sena and G{\'e}rard Rebel and Robert Bieth and Pierre Hubert and Albert Waksman",

note = "Funding Information: AS. is grateful to {\textquoteleft}Fundacao Calouste Gulbenkian{\textquoteright}. The authors are grateful to Mrs. Paulette Guerin and Marie-Claude Schickel for their technicala ssistancet,o Dr. C. Gardner for assistance in the linguistic revision of the manuscripta nd to Mrs. Claudine Thomassinf or careful typing of this paper.P art of this work was supportedb y the INSERM grant No. 803022b, y the FRMF and by the U.E.R. des Sciences BiomtdicalesU, .L.P. Strasbourg(L eg Ziring).G .R. and A.W. are Maitres de Recherche of the C.N.R.S.; P.H. is Attache de Recherche at I.N.S.E.R.M.",

year = "1982",

month = mar,

day = "12",

doi = "10.1016/0005-2760(82)90111-4",

language = "English",

volume = "710",

pages = "290--296",

journal = "Biochimica et Biophysica Acta - Lipids and Lipid Metabolism",

issn = "0005-2760",

publisher = "Elsevier BV",

number = "3",

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Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice. / Sena, Armando; Rebel, Gérard; Bieth, Robert et al.
Em: Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, Vol. 710, N.º 3, 12.03.1982, p. 290-296.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

AU - Sena, Armando

AU - Rebel, Gérard

AU - Bieth, Robert

AU - Hubert, Pierre

AU - Waksman, Albert

N1 - Funding Information: AS. is grateful to ‘Fundacao Calouste Gulbenkian’. The authors are grateful to Mrs. Paulette Guerin and Marie-Claude Schickel for their technicala ssistancet,o Dr. C. Gardner for assistance in the linguistic revision of the manuscripta nd to Mrs. Claudine Thomassinf or careful typing of this paper.P art of this work was supportedb y the INSERM grant No. 803022b, y the FRMF and by the U.E.R. des Sciences BiomtdicalesU, .L.P. Strasbourg(L eg Ziring).G .R. and A.W. are Maitres de Recherche of the C.N.R.S.; P.H. is Attache de Recherche at I.N.S.E.R.M.

PY - 1982/3/12

Y1 - 1982/3/12

N2 - Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

AB - Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

KW - (Mouse)

KW - Cholesterol

KW - Lipid composition

KW - Obesity

KW - Phosphatide fatty acid

UR - https://www.scopus.com/pages/publications/0020060156

U2 - 10.1016/0005-2760(82)90111-4

DO - 10.1016/0005-2760(82)90111-4

M3 - Article

C2 - 7074117

AN - SCOPUS:0020060156

SN - 0005-2760

VL - 710

SP - 290

EP - 296

JO - Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

JF - Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

IS - 3

ER -

Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

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