Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Ana B. Abecasis; Andreia Martins; Inês Costa; Ana P. Carvalho; Isabel Diogo; Perpétua Gomes; Ricardo J. Camacho

doi:10.1089/aid.2010.0312

Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Ana B. Abecasis
, Andreia Martins
, Inês Costa
, Ana P. Carvalho
, Isabel Diogo
, Perpétua Gomes
, Ricardo J. Camacho

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

9 Citações (Scopus)

Resumo

The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).

Idioma original	???core.languages.en_GB???
Páginas (de-até)	803-805
Número de páginas	3
Revista	AIDS Research and Human Retroviruses
Volume	27
Número de emissão	7
DOIs	https://doi.org/10.1089/aid.2010.0312
Estado da publicação	???researchoutput.status.published??? - 1 jul. 2011
Publicado externamente	Sim

ODS da ONU

Este resultado contribui para o(s) seguinte(s) Objetivo(s) de Desenvolvimento Sustentável

ODS 3 Boa saúde e bem-estar

Acesso ao documento

10.1089/aid.2010.0312

Outros arquivos e links

Link to publication in Scopus

Citar isto

@article{85a24885b88c47ce98b0815028e52009,

title = "Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients",

abstract = "The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7\%. When the subtype in pol and env was concordant (65.1\%), the most prevalent subtypes were subtype B (40.8\%), followed by subtype C (17.8\%) and subtype G (5.3\%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2\%).",

author = "Abecasis, \{Ana B.\} and Andreia Martins and In{\^e}s Costa and Carvalho, \{Ana P.\} and Isabel Diogo and Perp{\'e}tua Gomes and Camacho, \{Ricardo J.\}",

year = "2011",

month = jul,

day = "1",

doi = "10.1089/aid.2010.0312",

language = "English",

volume = "27",

pages = "803--805",

journal = "AIDS Research and Human Retroviruses",

issn = "0889-2229",

publisher = "SAGE Publications Ltd",

number = "7",

}

Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients. / Abecasis, Ana B.; Martins, Andreia; Costa, Inês et al.
Em: AIDS Research and Human Retroviruses, Vol. 27, N.º 7, 01.07.2011, p. 803-805.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

TY - JOUR

T1 - Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

AU - Abecasis, Ana B.

AU - Martins, Andreia

AU - Costa, Inês

AU - Carvalho, Ana P.

AU - Diogo, Isabel

AU - Gomes, Perpétua

AU - Camacho, Ricardo J.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).

AB - The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).

UR - https://www.scopus.com/pages/publications/79959826851

U2 - 10.1089/aid.2010.0312

DO - 10.1089/aid.2010.0312

M3 - Article

C2 - 21198411

AN - SCOPUS:79959826851

SN - 0889-2229

VL - 27

SP - 803

EP - 805

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 7

ER -

Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Resumo

ODS da ONU

Acesso ao documento

Outros arquivos e links

Impressão digital

Citar isto