TY - GEN
T1 - Morphologic changes in the parotid gland induced by low frequency noise - An histology study
AU - Oliveira, Pedro
AU - Dos Santos, José Martins
AU - Grande, Nuno Rodrigues
AU - Branco, Nuno Castelo
AU - Da Fonseca, Jorge
AU - Aves-Pereira, Mariana
PY - 2005
Y1 - 2005
N2 - The goal of this study is to evaluate the morphological abnormalities of the parotid gland of the Wistar rat exposed to low frequency noise (LFN) (=500Hz, infrasound included). Long-term exposure to LFN, may lead to the development of vibroacoustic disease, a multisystemic disease, characterized, among other abnormalities, by a excessive proliferation of extracelular matrix. METHODS: We studied 50 parotid glands of mice exposed to LFN for 2184 consecutive hours. The sections were stained with HE and PAS. RESULTS: Multiple alterations were observed, namely, vacuolar degenerescency (PAS negative) in the absence of inflammatory signs. Hialinization of connective tissue, cellular death and lobular necrosis were also observed. Important vascular changes, mainly in small vessels, with thickening of the walls, was found. DISCUSSION: There are no previous studies of LFN concerning the parotid gland. We found diffuse fibrosis of the connective tissue. The vacuolar degenerescency that we observed is also found in other pathological situations, such as ethanolic fat degenerescency, in "necrotising syalometaplasy", or in cases of irradiation with X-rays. The mechanism of LFN-caused lesions is not, yet, determined.
AB - The goal of this study is to evaluate the morphological abnormalities of the parotid gland of the Wistar rat exposed to low frequency noise (LFN) (=500Hz, infrasound included). Long-term exposure to LFN, may lead to the development of vibroacoustic disease, a multisystemic disease, characterized, among other abnormalities, by a excessive proliferation of extracelular matrix. METHODS: We studied 50 parotid glands of mice exposed to LFN for 2184 consecutive hours. The sections were stained with HE and PAS. RESULTS: Multiple alterations were observed, namely, vacuolar degenerescency (PAS negative) in the absence of inflammatory signs. Hialinization of connective tissue, cellular death and lobular necrosis were also observed. Important vascular changes, mainly in small vessels, with thickening of the walls, was found. DISCUSSION: There are no previous studies of LFN concerning the parotid gland. We found diffuse fibrosis of the connective tissue. The vacuolar degenerescency that we observed is also found in other pathological situations, such as ethanolic fat degenerescency, in "necrotising syalometaplasy", or in cases of irradiation with X-rays. The mechanism of LFN-caused lesions is not, yet, determined.
UR - http://www.scopus.com/inward/record.url?scp=84881591662&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84881591662
SN - 9781627481496
T3 - 12th International Congress on Sound and Vibration 2005, ICSV 2005
SP - 1516
EP - 1521
BT - 12th International Congress on Sound and Vibration 2005, ICSV 2005
T2 - 12th International Congress on Sound and Vibration 2005, ICSV 2005
Y2 - 11 July 2005 through 14 July 2005
ER -