TY - JOUR
T1 - Periodontitis and Systemic Lupus Erythematosus
T2 - A systematic review and meta-analysis
AU - Hussain, Syed Basit
AU - Leira, Yago
AU - Zehra, Syeda Ambreen
AU - Botelho, João
AU - Machado, Vanessa
AU - Ciurtin, Coziana
AU - D’Aiuto, Francesco
AU - Orlandi, Marco
N1 - Funding Information:
We would like to acknowledge that contribution for this work was undertaken at UCLH/UCL that received a proportion of funding from the Department of Health's NIHR Biomedical Research Centre funding scheme. Marco Orlandi held a NIHR Clinical Lectureship while Yago Leira a Senior Research Fellowship from the UCLH/UCL NIHR Biomedical Research Centre.
Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2022/1
Y1 - 2022/1
N2 - This systematic review and meta-analysis evaluated the association between periodontitis (PD) and systemic lupus erythematosus (SLE). A systematic search was conducted through the following electronic databases: Cochrane Library, MEDLINE, EMBASE, Scopus, LILACS, CINAHL and SIGLE (System for Information on Grey Literature in Europe) for relevant publications up to September 2020 with no language restriction. The association between PD and SLE was assessed by the prevalence of PD in SLE patients (both sex and females only) as the primary outcome. Secondary outcomes included differences in common gingival parameters including probing pocket depth (PPD), clinical attachment level (CAL), disease activity index (SLEDAI) scores of SLE patients with or without PD. A total of 1183 citations and 22 full text articles were screened. Eighteen articles were included in the qualitative synthesis, and 13 in the quantitative analysis. SLE diagnosis was associated with greater odds of PD (OR = 1.33, 95% Confidence Interval [CI]: 1.20–1.48), but these were non-significant when examined in females (OR = 3.20, 95%CI: 0.85–12.02). Patients with SLE exhibited no differences in PPD (SMD: −0.09 mm, 95%CI: −0.45–0.27) and CAL (SMD: 0.05 mm, 95%CI: −0.30–0.40) when compared with systemically healthy controls. PD diagnosis was, however, associated with higher SLEDAI scores in patients suffering from SLE (SMD: 0.68, 95% CI: 0.03–1.32). PD and SLE are both inflammatory diseases and their association could be bi-directional. This review suggested that the patients with SLE have greater odds of suffering with PD. Further investigations are required to assess the association between PD and SLE.
AB - This systematic review and meta-analysis evaluated the association between periodontitis (PD) and systemic lupus erythematosus (SLE). A systematic search was conducted through the following electronic databases: Cochrane Library, MEDLINE, EMBASE, Scopus, LILACS, CINAHL and SIGLE (System for Information on Grey Literature in Europe) for relevant publications up to September 2020 with no language restriction. The association between PD and SLE was assessed by the prevalence of PD in SLE patients (both sex and females only) as the primary outcome. Secondary outcomes included differences in common gingival parameters including probing pocket depth (PPD), clinical attachment level (CAL), disease activity index (SLEDAI) scores of SLE patients with or without PD. A total of 1183 citations and 22 full text articles were screened. Eighteen articles were included in the qualitative synthesis, and 13 in the quantitative analysis. SLE diagnosis was associated with greater odds of PD (OR = 1.33, 95% Confidence Interval [CI]: 1.20–1.48), but these were non-significant when examined in females (OR = 3.20, 95%CI: 0.85–12.02). Patients with SLE exhibited no differences in PPD (SMD: −0.09 mm, 95%CI: −0.45–0.27) and CAL (SMD: 0.05 mm, 95%CI: −0.30–0.40) when compared with systemically healthy controls. PD diagnosis was, however, associated with higher SLEDAI scores in patients suffering from SLE (SMD: 0.68, 95% CI: 0.03–1.32). PD and SLE are both inflammatory diseases and their association could be bi-directional. This review suggested that the patients with SLE have greater odds of suffering with PD. Further investigations are required to assess the association between PD and SLE.
UR - http://www.scopus.com/inward/record.url?scp=85116312649&partnerID=8YFLogxK
U2 - 10.1111/jre.12936
DO - 10.1111/jre.12936
M3 - Review article
C2 - 34608627
AN - SCOPUS:85116312649
SN - 0022-3484
VL - 57
SP - 1
EP - 10
JO - Journal of Periodontal Research
JF - Journal of Periodontal Research
IS - 1
ER -