Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Rita Tendeiro; Adriana S. Albuquerque; Russell B. Foxall; Rita Cavaleiro; Rui S. Soares; António P. Baptista; Maria V.D. Soares; Perpétua Gomes; Ana E. Sousa

doi:10.1097/QAD.0b013e32835ab234

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa

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Resumo

HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	289-292
Número de páginas	4
Revista	AIDS
Volume	27
Número de emissão	2
DOIs	https://doi.org/10.1097/QAD.0b013e32835ab234
Estado da publicação	???researchoutput.status.published??? - 14 jan. 2013

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title = "Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection",

abstract = "HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.",

author = "Rita Tendeiro and Albuquerque, {Adriana S.} and Foxall, {Russell B.} and Rita Cavaleiro and Soares, {Rui S.} and Baptista, {Ant{\'o}nio P.} and Soares, {Maria V.D.} and Perp{\'e}tua Gomes and Sousa, {Ana E.}",

year = "2013",

month = jan,

day = "14",

doi = "10.1097/QAD.0b013e32835ab234",

language = "English",

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journal = "AIDS",

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TY - JOUR

T1 - Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

AU - Tendeiro, Rita

AU - Albuquerque, Adriana S.

AU - Foxall, Russell B.

AU - Cavaleiro, Rita

AU - Soares, Rui S.

AU - Baptista, António P.

AU - Soares, Maria V.D.

AU - Gomes, Perpétua

AU - Sousa, Ana E.

PY - 2013/1/14

Y1 - 2013/1/14

N2 - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

AB - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

UR - http://www.scopus.com/inward/record.url?scp=84872416149&partnerID=8YFLogxK

U2 - 10.1097/QAD.0b013e32835ab234

DO - 10.1097/QAD.0b013e32835ab234

M3 - Article

C2 - 23032416

AN - SCOPUS:84872416149

SN - 0269-9370

VL - 27

SP - 289

EP - 292

JO - AIDS

JF - AIDS

IS - 2

ER -

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

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