Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Cristina Guimarães; Rui Bergantim; Renata Ramalho; Nuno Couto; João T. Guimarães; Fernanda Trigo

doi:10.1186/1756-8722-5-33

Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Cristina Guimarães
, Rui Bergantim
, Renata Ramalho
, Nuno Couto
, João T. Guimarães
, Fernanda Trigo

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.article??? › revisão de pares

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Resumo

Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

Idioma original	???core.languages.en_GB???
Número do artigo	33
Revista	Journal of Hematology and Oncology
Volume	5
DOIs	https://doi.org/10.1186/1756-8722-5-33
Estado da publicação	???researchoutput.status.published??? - 2012
Publicado externamente	Sim

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title = "Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy",

abstract = "Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.",

keywords = "Autologous stem cell transplantation, Marker of prognosis, Multiple myeloma, Serum immunofixation patterns",

author = "Cristina Guimar{\~a}es and Rui Bergantim and Renata Ramalho and Nuno Couto and Guimar{\~a}es, \{Jo{\~a}o T.\} and Fernanda Trigo",

year = "2012",

doi = "10.1186/1756-8722-5-33",

language = "English",

volume = "5",

journal = "Journal of Hematology and Oncology",

issn = "1756-8722",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

AU - Guimarães, Cristina

AU - Bergantim, Rui

AU - Ramalho, Renata

AU - Couto, Nuno

AU - Guimarães, João T.

AU - Trigo, Fernanda

PY - 2012

Y1 - 2012

N2 - Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

AB - Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

KW - Autologous stem cell transplantation

KW - Marker of prognosis

KW - Multiple myeloma

KW - Serum immunofixation patterns

UR - https://www.scopus.com/pages/publications/84865440214

U2 - 10.1186/1756-8722-5-33

DO - 10.1186/1756-8722-5-33

M3 - Article

C2 - 22734892

AN - SCOPUS:84865440214

SN - 1756-8722

VL - 5

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

M1 - 33

ER -

Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

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