Regenerative endodontics procedure: An umbrella review

Luísa Lopes; João Albernaz Neves; João Botelho; Vanessa Machado; José João Mendes

doi:10.3390/ijerph18020754

Regenerative endodontics procedure: An umbrella review

Luísa Lopes, João Albernaz Neves, João Botelho, Vanessa Machado, José João Mendes

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview??? › revisão de pares

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Resumo

The Regenerative Endodontic Procedure (REP) is a biologically based method in which a damaged pulp-dentin complex is replaced by a new vital tissue. This umbrella review aimed to critically assess the available systematic reviews (SRs) on REP. An electronic database search was conducted (PubMed-Medline, CENTRAL, Scielo, Web of Science, and LILACS) until December 2020. Studies were included if they were an SR on REP. The Risk of Bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). The primary outcome was the methodological quality in each specific section of REP protocols and outcomes. From 403 entries, 29 SRs were included. Regarding the methodological quality, ten studies were of critically low, three of low, fourteen of moderate, and two were rated as high quality. The quality of evidence produced by the available SRs was not favorable. Future high standard SRs and well-designed clinical trials are warranted to better elucidate the clinical protocols and outcomes of REP.

Idioma original	???core.languages.en_GB???
Número do artigo	754
Páginas (de-até)	1-17
Número de páginas	17
Revista	International Journal of Environmental Research and Public Health
Volume	18
Número de emissão	2
DOIs	https://doi.org/10.3390/ijerph18020754
Estado da publicação	???researchoutput.status.published??? - 2 jan. 2021

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title = "Regenerative endodontics procedure: An umbrella review",

abstract = "The Regenerative Endodontic Procedure (REP) is a biologically based method in which a damaged pulp-dentin complex is replaced by a new vital tissue. This umbrella review aimed to critically assess the available systematic reviews (SRs) on REP. An electronic database search was conducted (PubMed-Medline, CENTRAL, Scielo, Web of Science, and LILACS) until December 2020. Studies were included if they were an SR on REP. The Risk of Bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). The primary outcome was the methodological quality in each specific section of REP protocols and outcomes. From 403 entries, 29 SRs were included. Regarding the methodological quality, ten studies were of critically low, three of low, fourteen of moderate, and two were rated as high quality. The quality of evidence produced by the available SRs was not favorable. Future high standard SRs and well-designed clinical trials are warranted to better elucidate the clinical protocols and outcomes of REP.",

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author = "Lu{\'i}sa Lopes and Neves, {Jo{\~a}o Albernaz} and Jo{\~a}o Botelho and Vanessa Machado and Mendes, {Jos{\'e} Jo{\~a}o}",

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doi = "10.3390/ijerph18020754",

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Regenerative endodontics procedure: An umbrella review. / Lopes, Luísa ; Neves, João Albernaz ; Botelho, João et al.
Em: International Journal of Environmental Research and Public Health, Vol. 18, N.º 2, 754, 02.01.2021, p. 1-17.

Resultado de pesquisa: ???type-name??? › ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview??? › revisão de pares

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T1 - Regenerative endodontics procedure

T2 - An umbrella review

AU - Lopes, Luísa

AU - Neves, João Albernaz

AU - Botelho, João

AU - Machado, Vanessa

AU - Mendes, José João

PY - 2021/1/2

Y1 - 2021/1/2

N2 - The Regenerative Endodontic Procedure (REP) is a biologically based method in which a damaged pulp-dentin complex is replaced by a new vital tissue. This umbrella review aimed to critically assess the available systematic reviews (SRs) on REP. An electronic database search was conducted (PubMed-Medline, CENTRAL, Scielo, Web of Science, and LILACS) until December 2020. Studies were included if they were an SR on REP. The Risk of Bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). The primary outcome was the methodological quality in each specific section of REP protocols and outcomes. From 403 entries, 29 SRs were included. Regarding the methodological quality, ten studies were of critically low, three of low, fourteen of moderate, and two were rated as high quality. The quality of evidence produced by the available SRs was not favorable. Future high standard SRs and well-designed clinical trials are warranted to better elucidate the clinical protocols and outcomes of REP.

AB - The Regenerative Endodontic Procedure (REP) is a biologically based method in which a damaged pulp-dentin complex is replaced by a new vital tissue. This umbrella review aimed to critically assess the available systematic reviews (SRs) on REP. An electronic database search was conducted (PubMed-Medline, CENTRAL, Scielo, Web of Science, and LILACS) until December 2020. Studies were included if they were an SR on REP. The Risk of Bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). The primary outcome was the methodological quality in each specific section of REP protocols and outcomes. From 403 entries, 29 SRs were included. Regarding the methodological quality, ten studies were of critically low, three of low, fourteen of moderate, and two were rated as high quality. The quality of evidence produced by the available SRs was not favorable. Future high standard SRs and well-designed clinical trials are warranted to better elucidate the clinical protocols and outcomes of REP.

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KW - Endodontics

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Regenerative endodontics procedure: An umbrella review

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