Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

Luísa Custódio; Ana Luísa Escapa; João Patarra; Rosa Aligué; Fernando Alberício; Nuno Rosa Neng; José Manuel Florêncio Nogueira; Anabela Romano

Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

Luísa Custódio, Ana Luísa Escapa, João Patarra, Rosa Aligué, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira, Anabela Romano

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Resumo

Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	225-229
Número de páginas	5
Revista	Records of Natural Products
Volume	7
Número de emissão	3
Estado da publicação	???researchoutput.status.published??? - 28 mai. 2013
Publicado externamente	Sim

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title = "Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds",

abstract = "Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.",

keywords = "Antioxidant activity, Cytotoxic, Gentisic acid, Phenolic compounds, ROS",

author = "Lu{\'i}sa Cust{\'o}dio and Escapa, {Ana Lu{\'i}sa} and Jo{\~a}o Patarra and Rosa Aligu{\'e} and Fernando Alber{\'i}cio and Neng, {Nuno Rosa} and {Flor{\^e}ncio Nogueira}, {Jos{\'e} Manuel} and Anabela Romano",

year = "2013",

month = may,

day = "28",

language = "English",

volume = "7",

pages = "225--229",

journal = "Records of Natural Products",

issn = "1307-6167",

publisher = "ACG Publications",

number = "3",

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TY - JOUR

T1 - Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

AU - Custódio, Luísa

AU - Escapa, Ana Luísa

AU - Patarra, João

AU - Aligué, Rosa

AU - Alberício, Fernando

AU - Neng, Nuno Rosa

AU - Florêncio Nogueira, José Manuel

AU - Romano, Anabela

PY - 2013/5/28

Y1 - 2013/5/28

N2 - Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

AB - Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

KW - Antioxidant activity

KW - Cytotoxic

KW - Gentisic acid

KW - Phenolic compounds

KW - ROS

UR - http://www.scopus.com/inward/record.url?scp=84878435136&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84878435136

SN - 1307-6167

VL - 7

SP - 225

EP - 229

JO - Records of Natural Products

JF - Records of Natural Products

IS - 3

ER -

Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

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