Specific Insulin‐Mediated Regulation of Glutamine Synthetase in Cultured Chick Astroglial Cells

G. Tholey; A. H. Sena; M. Ledig

doi:10.1111/j.1471-4159.1986.tb00783.x

Specific Insulin‐Mediated Regulation of Glutamine Synthetase in Cultured Chick Astroglial Cells

G. Tholey, A. H. Sena, M. Ledig

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Abstract The expression of glutamine synthetase (GS; L‐glutamate ammonia ligase; EC 6.3.1.2) in primary cultures of chick astroglial cells and neurons grown in a chemically defined medium, with and without insulin added, was investigated. An inhibitory effect of insulin toward GS activity, and specific to chick astroglial cells, was observed. Neurons in culture were not sensitive to the hormone effect. Modulation of the activating effect of hydrocortisone onglial GS by insulin was also observed. The data suggest that insulin contributes to the regulation of the metabolism of amino acid neurotransmitters via its effect on GS.

Idioma original	???core.languages.en_GB???
Páginas (de-até)	1490-1492
Número de páginas	3
Revista	Journal of Neurochemistry
Volume	47
Número de emissão	5
DOIs	https://doi.org/10.1111/j.1471-4159.1986.tb00783.x
Estado da publicação	???researchoutput.status.published??? - nov. 1986
Publicado externamente	Sim

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title = "Specific Insulin‐Mediated Regulation of Glutamine Synthetase in Cultured Chick Astroglial Cells",

abstract = "Abstract The expression of glutamine synthetase (GS; L‐glutamate ammonia ligase; EC 6.3.1.2) in primary cultures of chick astroglial cells and neurons grown in a chemically defined medium, with and without insulin added, was investigated. An inhibitory effect of insulin toward GS activity, and specific to chick astroglial cells, was observed. Neurons in culture were not sensitive to the hormone effect. Modulation of the activating effect of hydrocortisone onglial GS by insulin was also observed. The data suggest that insulin contributes to the regulation of the metabolism of amino acid neurotransmitters via its effect on GS.",

keywords = "Chick astroglial cells, Chick neurons, Glutamine synthetase, Hydro‐cortisone effect, Insulin effect, Primary cultures",

author = "G. Tholey and Sena, {A. H.} and M. Ledig",

year = "1986",

month = nov,

doi = "10.1111/j.1471-4159.1986.tb00783.x",

language = "English",

volume = "47",

pages = "1490--1492",

journal = "Journal of Neurochemistry",

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T1 - Specific Insulin‐Mediated Regulation of Glutamine Synthetase in Cultured Chick Astroglial Cells

AU - Tholey, G.

AU - Sena, A. H.

AU - Ledig, M.

PY - 1986/11

Y1 - 1986/11

N2 - Abstract The expression of glutamine synthetase (GS; L‐glutamate ammonia ligase; EC 6.3.1.2) in primary cultures of chick astroglial cells and neurons grown in a chemically defined medium, with and without insulin added, was investigated. An inhibitory effect of insulin toward GS activity, and specific to chick astroglial cells, was observed. Neurons in culture were not sensitive to the hormone effect. Modulation of the activating effect of hydrocortisone onglial GS by insulin was also observed. The data suggest that insulin contributes to the regulation of the metabolism of amino acid neurotransmitters via its effect on GS.

AB - Abstract The expression of glutamine synthetase (GS; L‐glutamate ammonia ligase; EC 6.3.1.2) in primary cultures of chick astroglial cells and neurons grown in a chemically defined medium, with and without insulin added, was investigated. An inhibitory effect of insulin toward GS activity, and specific to chick astroglial cells, was observed. Neurons in culture were not sensitive to the hormone effect. Modulation of the activating effect of hydrocortisone onglial GS by insulin was also observed. The data suggest that insulin contributes to the regulation of the metabolism of amino acid neurotransmitters via its effect on GS.

KW - Chick astroglial cells

KW - Chick neurons

KW - Glutamine synthetase

KW - Hydro‐cortisone effect

KW - Insulin effect

KW - Primary cultures

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DO - 10.1111/j.1471-4159.1986.tb00783.x

M3 - Article

C2 - 2876055

AN - SCOPUS:0023010362

SN - 0022-3042

VL - 47

SP - 1490

EP - 1492

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

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Specific Insulin‐Mediated Regulation of Glutamine Synthetase in Cultured Chick Astroglial Cells

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