Structure and function of human matrix metalloproteinases

Helena Laronha; Jorge Caldeira

doi:10.3390/cells9051076

Structure and function of human matrix metalloproteinases

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Resumo

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

Idioma original	???core.languages.en_GB???
Número do artigo	1076
Revista	Cells
Volume	9
Número de emissão	5
DOIs	https://doi.org/10.3390/cells9051076
Estado da publicação	???researchoutput.status.published??? - mai. 2020

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title = "Structure and function of human matrix metalloproteinases",

abstract = "The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.",

keywords = "Collagen, Matrix metalloproteinases, TIMP",

author = "Helena Laronha and Jorge Caldeira",

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AU - Laronha, Helena

AU - Caldeira, Jorge

PY - 2020/5

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AB - The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

KW - Collagen

KW - Matrix metalloproteinases

KW - TIMP

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DO - 10.3390/cells9051076

M3 - Review article

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Structure and function of human matrix metalloproteinases

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