The role of Phaseolus vulgaris in DMBA-induced sprague-dawley rat mammary carcinomas

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Resumo

The present study intended to study the influence of Phaseolus vulgaris beans in mammary carcinogenesis especially considering the main malignancy indicators through a histopathology study. A total of 72 female rats 50 days old were divided in three groups and hold in constant conditions temperature, light and humidity. Group B and C received 20 mg of 7, 12 dimethyl benzanthracene by gavages. All the animals were fed with the same standard food, group C were supplemented with Phaseolus vulgaris beans. The study had last for 150 days. Tumors in group C animals had lower pattern grades and lower mitotic counts despite the higher weight gain in this group. These results suggest a protective role of bean consumption in mammary carcinogenesis possibly due to fiber and oligossacharides content, especially present in Phaseolus vulgaris from "padrão tarrestre" species.

Idioma original???core.languages.en_GB???
Páginas (de-até)125-134
Número de páginas10
RevistaInternational Journal of Cancer Research
Volume7
Número de emissão2
DOIs
Estado da publicação???researchoutput.status.published??? - 2011

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