Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Eduarda M.P. Silva; Francesca Giuntini; Maria A.F. Faustino; João P.C. Tomé; Maria G.P.M.S. Neves; Augusto C. Tomé; Artur M.S. Silva; Maria G. Santana-Marques; António J. Ferrer-Correia; José A.S. Cavaleiro; Maria F. Caeiro; Ricardo R. Duarte; Sabina A.P. Tavares; Inês N. Pegado; Bruno D'Almeida; António P.A. De Matos; Maria L. Valdeira

doi:10.1016/j.bmcl.2005.05.044

Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Eduarda M.P. Silva
, Francesca Giuntini
, Maria A.F. Faustino
, João P.C. Tomé
, Maria G.P.M.S. Neves
, Augusto C. Tomé
, Artur M.S. Silva
, Maria G. Santana-Marques
, António J. Ferrer-Correia
, José A.S. Cavaleiro
, Maria F. Caeiro
, Ricardo R. Duarte
, Sabina A.P. Tavares
, Inês N. Pegado
, Bruno D'Almeida
, António P.A. De Matos
, Maria L. Valdeira

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

An easy route to cationic β-vinyl substituted meso- tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.

Original language	English
Pages (from-to)	3333-3337
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.044
Publication status	Published - 15 Jul 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aldol condensation
HSV-1
Herpesviruses
Porphyrins

Access to Document

10.1016/j.bmcl.2005.05.044

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Silva, E. M. P., Giuntini, F., Faustino, M. A. F., Tomé, J. P. C., Neves, M. G. P. M. S., Tomé, A. C., Silva, A. M. S., Santana-Marques, M. G., Ferrer-Correia, A. J., Cavaleiro, J. A. S., Caeiro, M. F., Duarte, R. R., Tavares, S. A. P., Pegado, I. N., D'Almeida, B., De Matos, A. P. A., & Valdeira, M. L. (2005). Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1. Bioorganic and Medicinal Chemistry Letters, 15(14), 3333-3337. https://doi.org/10.1016/j.bmcl.2005.05.044

@article{8db5dfbe3fc343108425a9d53d112feb,

title = "Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1",

abstract = "An easy route to cationic β-vinyl substituted meso- tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99\% of virus inactivation after 15 min of photoactivation.",

keywords = "Aldol condensation, HSV-1, Herpesviruses, Porphyrins",

author = "Silva, \{Eduarda M.P.\} and Francesca Giuntini and Faustino, \{Maria A.F.\} and Tom{\'e}, \{Jo{\~a}o P.C.\} and Neves, \{Maria G.P.M.S.\} and Tom{\'e}, \{Augusto C.\} and Silva, \{Artur M.S.\} and Santana-Marques, \{Maria G.\} and Ferrer-Correia, \{Ant{\'o}nio J.\} and Cavaleiro, \{Jos{\'e} A.S.\} and Caeiro, \{Maria F.\} and Duarte, \{Ricardo R.\} and Tavares, \{Sabina A.P.\} and Pegado, \{In{\^e}s N.\} and Bruno D'Almeida and \{De Matos\}, \{Ant{\'o}nio P.A.\} and Valdeira, \{Maria L.\}",

note = "Funding Information: We gratefully acknowledge FCT-FEDER for funding (Project POCTI/38750/FCB/2001) and financial support of the Research Unit “Qu{\'i}mica Org{\^a}nica, Produtos Naturais e Agro-Alimentares.” F.G. and J.P.C.T. are grateful to FCT for their post-doctoral grants. E.M.P.S., R.R.D. and I.N.P. are grateful to FCT for their BIC grants. ",

year = "2005",

month = jul,

day = "15",

doi = "10.1016/j.bmcl.2005.05.044",

language = "English",

volume = "15",

pages = "3333--3337",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "14",

}

Silva, EMP, Giuntini, F, Faustino, MAF, Tomé, JPC, Neves, MGPMS, Tomé, AC, Silva, AMS, Santana-Marques, MG, Ferrer-Correia, AJ, Cavaleiro, JAS, Caeiro, MF, Duarte, RR, Tavares, SAP, Pegado, IN, D'Almeida, B, De Matos, APA & Valdeira, ML 2005, 'Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 14, pp. 3333-3337. https://doi.org/10.1016/j.bmcl.2005.05.044

TY - JOUR

T1 - Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

AU - Silva, Eduarda M.P.

AU - Giuntini, Francesca

AU - Faustino, Maria A.F.

AU - Tomé, João P.C.

AU - Neves, Maria G.P.M.S.

AU - Tomé, Augusto C.

AU - Silva, Artur M.S.

AU - Santana-Marques, Maria G.

AU - Ferrer-Correia, António J.

AU - Cavaleiro, José A.S.

AU - Caeiro, Maria F.

AU - Duarte, Ricardo R.

AU - Tavares, Sabina A.P.

AU - Pegado, Inês N.

AU - D'Almeida, Bruno

AU - De Matos, António P.A.

AU - Valdeira, Maria L.

N1 - Funding Information: We gratefully acknowledge FCT-FEDER for funding (Project POCTI/38750/FCB/2001) and financial support of the Research Unit “Química Orgânica, Produtos Naturais e Agro-Alimentares.” F.G. and J.P.C.T. are grateful to FCT for their post-doctoral grants. E.M.P.S., R.R.D. and I.N.P. are grateful to FCT for their BIC grants.

PY - 2005/7/15

Y1 - 2005/7/15

N2 - An easy route to cationic β-vinyl substituted meso- tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.

AB - An easy route to cationic β-vinyl substituted meso- tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.

KW - Aldol condensation

KW - HSV-1

KW - Herpesviruses

KW - Porphyrins

UR - https://www.scopus.com/pages/publications/20644438450

U2 - 10.1016/j.bmcl.2005.05.044

DO - 10.1016/j.bmcl.2005.05.044

M3 - Article

C2 - 15951174

AN - SCOPUS:20644438450

SN - 0960-894X

VL - 15

SP - 3333

EP - 3337

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Abstract

UN SDGs

Keywords

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